Pooky or Pookie may refer to:
- Originally a hand puppet (Pookie the Lion) on the Soupy Sales television show.
- The Sterile Cuckoo, a 1969 film released in the UK as Pookie.
- Pookie (vehicle), a Rhodesian mine-detecting vehicle.
- Mr. Pookie (b. 1978), an American rapper
- Pooky (character), the teddy bear belonging to the cat Garfield in the comic strip Garfield
- Pookie (rabbit) lead character in popular children's stories by Ivy Wallace
- Pooky Night, an alternate name for Halloween in some parts of Ireland.